Synthesis of a newly peptide nucleic acid that contains tertiary amino groups
نویسندگان
چکیده
منابع مشابه
Facile synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates on an automated peptide synthesizer.
Peptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence-specific manner. Therefore, they are widely used in molecular diagnosis of antisense-...
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Inhibition of gene expression is of great interest to explore gene function or for therapeutic applications. Oligonucleotides that interact with a specific RNA (antisense strategy) or DNA (antigene strategy) sequence are very attractive to disrupt gene expression. Structural modifications brought to the last generation of oligonucleotides like PNAs (peptide nucleic acids) have led to molecules ...
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Aminoglycoside antibiotics (Figs. 1 and 2), containing a unique polyamine/ carbohydrate structure, have attracted considerable attention because of their specific interactions with RNA. Their antibacterial activity is mainly exerted by their binding to the RNA of the bacterial ribosome, and thus interfering with the mRNA translation process. The miscoding causes membrane damage, which eventuall...
متن کاملSequence-Specific Nucleic Acid Damage by Peptide Nucleic Acid Conjugates That Can Be
Inhibition of gene expression is of great interest to explore gene function or for therapeutic applications. Oligonucleotides that interact with a specific RNA (antisense strategy) or DNA (antigene strategy) sequence are very attractive to disrupt gene expression. Structural modifications brought to the last generation of oligonucleotides like PNAs (peptide nucleic acids) have led to molecules ...
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A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ester. This process allows for a concomitant ...
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ژورنال
عنوان ژورنال: Nucleic Acids Symposium Series
سال: 2005
ISSN: 1746-8272,0261-3166
DOI: 10.1093/nass/49.1.363